Scientific papers

CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability.

Joković D, Milosavljević F, Stojanović Z, Šupić G, Vojvodić D, Uzelac B, Jukić MM, Petković Ćurčin A.

Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status With Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis.

Milosavljevic F, Bukvic N, Pavlovic Z, Miljevic C, Pešic V, Molden E, Ingelman-Sundberg M, Leucht S, Jukic MM.

Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients.

Miljević ČD, Nikolić-Kokić A, Blagojević D, Milovanović M, Munjiza A, Jukić MM, Pešić V, Lečić-Toševski D, Spasić MB.

Association Between CYP2D6 Metabolizer Status and Vortioxetine Exposure and Treatment Switching: A Retrospective, Naturalistic Cohort Study Using Therapeutic Drug Monitoring Data From 640 Patients.

Frederiksen T, Smith RL, Jukic MM, Molden E.
J Clin Psychopharmacol. 2022 Jul-Aug 01;42(4):396-399. doi: 10.1097/JCP.0000000000001563. Epub 2022 Jun 13.
PMID: 35703273

Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population.

Bråten LS, Ingelman-Sundberg M, Jukic MM, Molden E, Kringen MK.
Clin Transl Sci. 2022 Jun 6. doi: 10.1111/cts.13347. Online ahead of print.
PMID: 35668575

Hepatocyte Thorns, A Novel Drug-Induced Stress Response in Human and Mouse Liver Spheroids.

Pridgeon CS, Bolhuis DP, Milosavljević F, Manojlović M, Végvári Á, Gaetani M, Jukić MM, Ingelman-Sundberg M.
Cells. 2022 May 10;11(10):1597. doi: 10.3390/cells11101597.
PMID: 35626634 Free PMC article.

CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability.

Joković D, Milosavljević F, Stojanović Z, Šupić G, Vojvodić D, Uzelac B, Jukić MM, Petković Ćurčin A.
Psychiatry Res. 2022 Jun;312:114535. doi: 10.1016/j.psychres.2022.114535. Epub 2022 Mar 31.
PMID: 35398660 Free article.

The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients.

Lenk HÇ, Klöditz K, Johansson I, Smith RL, Jukić MM, Molden E, Ingelman-Sundberg M.
Clin Pharmacol Ther. 2022 May;111(5):1165-1174. doi: 10.1002/cpt.2571. Epub 2022 Mar 20.
PMID: 35253216 Free PMC article.

CYP2D6 Reduced Function Variants and Genotype/Phenotype Translations of CYP2D6 Intermediate Metabolizers: Implications for Personalized Drug Dosing in Psychiatry.

Molden E, Jukić MM.
Front Pharmacol. 2021 Apr 22;12:650750. doi: 10.3389/fphar.2021.650750. eCollection 2021.
PMID: 33967790 Free PMC article.

Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy.

Stanić D, Oved K, Israel-Elgali I, Jukić M, Batinić B, Puškaš N, Shomron N, Gurwitz D, Pešić V.
Psychoneuroendocrinology. 2021 Jul;129:105234. doi: 10.1016/j.psyneuen.2021.105234. Epub 2021 Apr 18.
PMID: 33930757

Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates.

Jukić MM, Smith RL, Molden E, Ingelman-Sundberg M.
Clin Pharmacol Ther. 2021 Sep;110(3):750-758. doi: 10.1002/cpt.2246. Epub 2021 May 2.
PMID: 33792048

A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram.

Bråten LS, Haslemo T, Jukic MM, Ivanov M, Ingelman-Sundberg M, Molden E, Kringen MK.
Clin Pharmacol Ther. 2021 Sep;110(3):786-793. doi: 10.1002/cpt.2233. Epub 2021 Apr 13.
PMID: 33759177

Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status With Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis.

Milosavljevic F, Bukvic N, Pavlovic Z, Miljevic C, Pešic V, Molden E, Ingelman-Sundberg M, Leucht S, Jukic MM.
JAMA Psychiatry. 2021 Mar 1;78(3):270-280. doi: 10.1001/jamapsychiatry.2020.3643.
PMID: 33237321 Free PMC article.

Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders.

Smith RL, Tveito M, Kyllesø L, Jukic MM, Ingelman-Sundberg M, Andreassen OA, Molden E.
Schizophr Res. 2021 Feb;228:590-596. doi: 10.1016/j.schres.2020.11.025. Epub 2020 Nov 19.
PMID: 33221147

Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats.

Kapor S, Aksić M, Puškaš L, Jukić M, Poleksić J, Milosavljević F, Bjelica S, Filipović B.
Front Neuroanat. 2020 Oct 23;14:578900. doi: 10.3389/fnana.2020.578900. eCollection 2020.
PMID: 33192342 Free PMC article.

Can G_i1 biased 5-HT_2A inverse agonists improve the treatment of psychosis?

Jukić MM.
Eur Neuropsychopharmacol. 2020 Aug;37:100-101. doi: 10.1016/j.euroneuro.2020.06.012. Epub 2020 Jul 16.
PMID: 32684493 No abstract available.

Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs – A study based on blood sample analyses from 24,239 patients.

Smith RL, Tveito M, Kyllesø L, Jukic MM, Ingelman-Sundberg M, Andreassen OA, Molden E.
Eur Neuropsychopharmacol. 2020 Aug;37:64-69. doi: 10.1016/j.euroneuro.2020.06.007. Epub 2020 Jun 25.
PMID: 32595082 Clinical Trial.

Pharmacogenomics of Antidepressant and Antipsychotic Treatment: How Far Have We Got and Where Are We Going?

van Westrhenen R, Aitchison KJ, Ingelman-Sundberg M, Jukić MM.
Front Psychiatry. 2020 Mar 12;11:94. doi: 10.3389/fpsyt.2020.00094. eCollection 2020.
PMID: 32226396 Free PMC article. Review.

Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients.

Bråten LS, Haslemo T, Jukic MM, Ingelman-Sundberg M, Molden E, Kringen MK.
Neuropsychopharmacology. 2020 Feb;45(3):570-576. doi: 10.1038/s41386-019-0554-x. Epub 2019 Oct 24.
PMID: 31649299 Free PMC article.

Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study.

Jukic MM, Smith RL, Haslemo T, Molden E, Ingelman-Sundberg M.
Lancet Psychiatry. 2019 May;6(5):418-426. doi: 10.1016/S2215-0366(19)30088-4. Epub 2019 Apr 15.
PMID: 31000417

Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D641 versus CYP2D69 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients.

Haslemo T, Eliasson E, Jukić MM, Ingelman-Sundberg M, Molden E.
Br J Clin Pharmacol. 2019 Jan;85(1):194-201. doi: 10.1111/bcp.13788. Epub 2018 Nov 11.
PMID: 30312494 Free PMC article.

Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients.

Miljević ČD, Nikolić-Kokić A, Blagojević D, Milovanović M, Munjiza A, Jukić MM, Pešić V, Lečić-Toševski D, Spasić MB.
Psychiatry Res. 2018 Nov;269:746-752. doi: 10.1016/j.psychres.2018.09.009. Epub 2018 Sep 5.
PMID: 30273900

Functional characterization of CYP2D7 gene variants.

Jukic MM, Lauschke VM, Saito T, Hiratsuka M, Ingelman-Sundberg M.
Pharmacogenomics. 2018 Aug 1;19(12):931-936. doi: 10.2217/pgs-2018-0065. Epub 2018 Jul 24.
PMID: 30040020

Corrigendum: Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool.

Zega K, Jovanovic VM, Vitic Z, Niedzielska M, Knaapi L, Jukic MM, Partanen J, Friedel RH, Lang R, Brodski C.
Front Mol Neurosci. 2018 Feb 1;11:29. doi: 10.3389/fnmol.2018.00029. eCollection 2018.
PMID: 29417959 Free PMC article.

Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients.

Jukić MM, Haslemo T, Molden E, Ingelman-Sundberg M.
Am J Psychiatry. 2018 May 1;175(5):463-470. doi: 10.1176/appi.ajp.2017.17050550. Epub 2018 Jan 12.
PMID: 29325448

BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.

Jovanovic VM, Salti A, Tilleman H, Zega K, Jukic MM, Zou H, Friedel RH, Prakash N, Blaess S, Edenhofer F, Brodski C.
J Neurosci. 2018 Feb 14;38(7):1662-1676. doi: 10.1523/JNEUROSCI.1540-17.2018. Epub 2018 Jan 10.
PMID: 29321139 Free PMC article.

Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool.

Zega K, Jovanovic VM, Vitic Z, Niedzielska M, Knaapi L, Jukic MM, Partanen J, Friedel RH, Lang R, Brodski C.
Front Mol Neurosci. 2017 Nov 9;10:372. doi: 10.3389/fnmol.2017.00372. eCollection 2017. PMID: 29170629 Free PMC article.